Dr. Kibel has been awarded by the National Institutes of Health and the National Cancer Institute for his study, “Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer.”
The premise of this study is that an optimal early detection strategy to identify clinically relevant prostate cancer will involve a two-tiered algorithm that leverages inherited genetic information to determine who is at risk for prostate cancer followed by MRI imaging to determine which of these high-risk patients has clinically relevant disease. We propose to test this premise by implementing a polygenic risk score in men and conducting a prospective trial among 1,500 men with MRI to prove the two-tiered algorithm works. Collaborators include: Harvard T.H. Chan School of Public Health, Howard University Cancer Center, The Center for Cancer Research of the NCI, The Division of Cancer Epidemiology and Genetics (DCEG) of the NCI, and the Center for Prostate Disease Research of the Uniformed Services University of Health Sciences (USU), Walter Reed National Military Medical Center (WRNMMC), Murtha Cancer Center Research Program (MCCRP) and Urology Service at WRNMMC.
Adam S. Kibel, MD
Chief, Division of Urology, Brigham and Women’s Hospital
DiNovi Family Distinguished Chair in Urology, Brigham and Women’s Hospital
Elliott Carr Cutler Professor of Surgery in Urology, Harvard Medical School
Dr. Kibel is chief of Urology at Brigham and Women’s Hospital and Dana-Farber Brigham Cancer Center and the inaugural incumbent of the DiNovi Family Distinguished Chair in Urology at Brigham and Women’s Hospital. He received his undergraduate and medical degrees from Cornell University, completed his urology residency at the Harvard Urologic Surgery Residency Program and fellowship training at the Johns Hopkins Brady Urological Institute.
With a practice focused on minimally invasive treatments for urologic cancers, Dr. Kibel has been listed as one of America’s Top Doctors by Castle Connolly and named a top urologist by Boston Magazine. The author of close to 400 peer-reviewed publications, Dr. Kibel’s research focuses on the identification of molecular markers of urologic tumors, adjuvant and neoadjuvant approaches to treatment of aggressive disease, and improved imaging of patients with urologic malignancies. His research has been supported by multiple organizations including the National Cancer Institute, the American Cancer Society, the American College of Surgeons and the American Foundation for Urologic Disease.